Nao Kanzaki is a college student who is known for her honesty and naivete. One day, she receives a black postcard indicating that she has been selected to participate in the "Liar Game Tournament". Along with the postcard is a box with 100 million yen. The goal of the first round of the game is to trick the other player out of their hundred million yen. At the end, the winner would get to keep the hundred million earned, and the loser owes the LGT 100 million yen, which "will be collected by any means and at all costs".
The naïve Kanzaki Nao and expert swindler Akiyama Shinichi have not heard anything from the LIAR GAME organization since the end of the previous game, so it seems they may have actually escaped. But Nao suddenly gets another invitation and is once again caught up in the game. This time, she has to team up with Shinichi and one of their previous rivals named Fukunaga, facing off against three more opponents in new games of deception, such as "24 Rensou Russian Roulette" and "17 Poker."